Bycombining broad expertise in siRNA science with proven delivery platformsand a strong and growing IP position, MDRNA is well positioned as aleading RNAi therapeutics company and value-added collaborator for ourresearch partners Additional information about MDRNA, Inc. We are also building on newtechnologies, such as UsiRNAs that incorporate the non-nucleotide moietyUnlocked Nucleobase Analog (UNA) within the siRNA molecule, that weexpect to lead to safer and more effective RNAi-based therapeutics. Ourmulti-disciplinary portfolio of capabilities includes molecular biology,cellular biology, formulation expertise, peptide and alkylated amino acidchemistry, pharmacology, toxicology and bioinformatics. We are applyingthis expertise to a single, integrated drug discovery platform that willbe the engine for our clinical pipeline and a versatile platform forestablishing broad therapeutic partnerships. Our goal is to improve human health by combining novel RNAi-basedcompounds and proprietary peptide- and liposomal-based drug deliverytechnologies to provide superior therapeutic options.

Wewill continue to speak with and look for other prominent scientists as webuild our Scientific Advisory Board.”About MDRNA, Inc.MDRNA is a biotechnology company focused on the development andcommercialization of therapeutic products based on RNA interference(RNAi). Davidson and Novina willcontribute greatly to the achievement of our key scientific objectives. Phillip Sharp, Nobel Laureate, atMassachusetts Institute of Technology investigating small RNA-directedgene silencing.Dr Polisky added, “I am confident both Drs. from Tufts University,Sackler School of Graduate Biomedical Sciences in 1998. He did hisgraduate studies on transcriptional regulation of TATA-less promoters byTFII-I in Dr Ananda Roy’s laboratory Dr Novina completed hispostdoctoral training with Dr. from Columbia University, College ofPhysicians and Surgeons in 2000 and his Ph.D. His laboratory is engaged in collaborative projects toprofile microRNA expression as well as microRNA and RNAi factor gene loci,in an effort to understand the roles of microRNAs in cancer, includinghematopoietic and solid tumors.Dr Novina received his M.D.

His research focuses on investigating the mechanisms andapplications of mammalian RNAi. To discover the biological roles ofmicroRNAs and their interacting proteins, his group has developedcell-free, microRNA-dependent translational gene silencing reactions andcell-based reporter systems for translational repression and mRNA cleavageby microRNAs. Novina is an Assistant Professor in the Department of Pathology atHarvard Medical School, an Assistant Professor of Cancer Immunology/AIDSat Dana-Farber Cancer Institute and an Associate Member at the BroadInstitute. from the University of Michigan in 1987and was a Fellow of the University of Michigan from 1990 to 1992.Carl Novina, M.D., Ph.D.Dr. Davidsonserves on the Board of Directors for the American Society for GeneTherapy, and is Associate Director of the Center for Gene Therapy forCystic Fibrosis and other Genetic Diseases, and is past Co-Director ofthe Iowa Biosciences Advantage Program.Dr Davidson received her Ph.D. Davidson is a member of the American Association for theAdvancement of Science, American Federation for Clinical Research(Midwest Section), American Society for Neuroscience, American Societyfor Gene Therapy, and the American Society for Microbiology Dr.

Carver Biomedical Research Chair and isDirector of The Davidson Laboratory, which is focused on inheritedgenetic diseases that cause central nervous system dysfunction, with afocus on (1) recessive, childhood onset neurodegenerative disease, inparticular the lysosomal storage diseases such as themucopolysaccharidoses and Battens disease; and (2) dominant geneticdiseases for example the CAG repeat disorders, Huntington’s disease andspinal cerebellar ataxia type I, and (3), understanding how noncodingRNAs participate in neural development and neurodegenerative diseasesprocesses Dr. Novina previously served on MDRNA’sSAB during 2008.”Beverly L Davidson, Ph.D.Dr. Davidson is currently Professor of Medicine, Neurology and Physiology& Biophysics in the Department of Internal Medicine at The University ofIowa She holds the Roy J. During my tenure at Sirna Therapeutics, I worked with Dr.Davidson on our SAB, and of course Dr.